US specialists treating international patients
Ruth Kriz (nurse practitioner)
2604 Connecticut Avenue NW, Suite 300, Washington, DC 20008
T. 0011 +1 202 714 2415
Women are the most common group afflicted by UTIs. However, UTIs also affect babies, children, men and especially the elderly.
UTIs are common in otherwise healthy adult women, but there are some medical conditions that can increase their likelihood. These include diabetes, conditions causing immunosuppression, physical injuries impacting the spine/pelvis and conditions requiring catheterisation1.
1 Foxman, B., Epidemiology of urinary tract infections: Incidence, morbidity, and economic costs. Disease-a-Month, 49(2), 53-70, 2003; doi: 10.1016/S0011-5029(03)90000-9 www.ncbi.nlm.nih. gov/pubmed/12601337
An estimated 50% of all women will experience an acute UTI in their lifetime2. This means, even if you have not had a UTI yourself, someone close to you has. To explain the difference between an acute and chronic UTI, we need to delve into some science.
During an acute UTI, pathogenic bacteria invade the urethra/bladder and multiply rapidly in the urine. This is known as a planktonic infection. An acute (planktonic) UTI will result in the sudden onset of one or more of the distressing UTI symptoms most Australian women are familiar with—painful urination (dysuria), urgency, extreme frequency, excruciating bladder/lower abdominal pain, lower back pain and, sometimes, cloudy, smelly or even blood-filled urine.
A chronic UTI presents differently because the bacteria have become embedded within the lining of the bladder/urinary tract. Anyone who has an acute UTI is at risk of the infection becoming chronic. In fact, most people with a chronic UTI can clearly pinpoint the origins of their symptoms after an acute UTI did not fully resolve after treatment. This is because, in some circumstances when treating an acute UTI, bacteria can evade the host immunity or antibiotic attack. For safety, they cleverly burrow into the cells that form the bladder lining (known as the urothelium) and/or gather in tight clusters covered in a sticky substance called biofilm. Once embedded in the urothelium, the infection becomes increasingly difficult to diagnose using current testing tools and is challenging to treat3,4.
2 Foxman, B. (2003). Epidemiology of urinary tract infections: Incidence, morbidity, and economic costs. Disease-a-Month, 49(2), 53-70. doi: 10.1016/S0011-5029(03)90000-9 www.ncbi. nlm.nih.gov/pubmed/12601337
3 Professor James Malone-Lee, Emeritus Professor of Nephrology, University College London, personal communication, 27 January 2018 www.chronicutiaustralia.com/chronic-uti/how-chronic-uti-forms/ Accessed 15 September 2018
4 Rosen DA, Hooton TM, Stamm WE, Humphrey PA, Hultgren SJ., Detection of intracellular bacterial communities in human urinary tract infection. PLoSMed. 2007;4(12):e329 www.ncbi.nlm.nih.gov/pubmed/15337164
Chronic UTI can present in several ways. It can occur as recurrent acute UTIs, often increasing in frequency and severity over time. Alternatively, chronic UTI can feature constant background urinary symptoms (that usually appear negative on dipsticks and MSU culture tests) and acute attacks known as ‘flares’.
Chronic UTI symptoms can include some, or all, of the symptoms experienced during an acute UTI, along with chronic bladder/pelvic pain, urethral/vulval pain, overactive bladder, stress urinary incontinence, voiding problems and frequency symptoms. Typically, people with chronic UTI will suffer these painful, relentless and often debilitating symptoms for many years or even entire lifetimes.
There are two tests currently used to diagnose UTIs that were developed and introduced in the 1950s—the urinary dipstick and the MSU culture. There is also a new form of UTI testing, molecular (DNA) testing, which has recently become commercially available through several labs in the United States.
The urinary dipstick is used by doctors as a basic first-line diagnostic tool. It is designed to pick up signs of an acute UTI, such as leukocyte esterase (signs of pus/white blood cells), nitrites (produced by some types of gram negative bacteria) and blood. Urinary dipsticks have been widely discredited, with research showing they miss up to 70% of infections6,7,8. They can be useful in confirming a clearly positive acute infection,
but dipsticks are ineffective at ruling out infection.
Cultures are performed in clinical labs to grow and identify the bacteria responsible for an infection. They are also used to determine any antibiotic resistance the identified bacteria may harbour. The MSU culture was originally developed to diagnose pyelonephritis (a kidney infection)—a much more severe and serious form of acute upper urinary tract infection.
Although the culture, along with its set of arbitrary diagnostic thresholds, was never validated for diagnosing acute UTIs, it somehow became adopted worldwide as the ‘gold standard’ tool for UTI diagnosis. For the past 30 years, researchers have been demonstrating that MSU culture tests are fundamentally flawed and miss 50–80% of UTIs8,9.
Traditionally, culture testing has been mostly satisfactory for the majority of uncomplicated, acute UTIs caused by Escherichia coli (E. coli), and several other known urinary pathogens. However, research shows this ‘gold standard’ test fails to diagnose chronic UTI, complicated and polymicrobial UTIs, lower grade UTIs and infections caused by more recently recognised uropathogens10.
DNA-based molecular testing for diagnosing UTIs is generating interest because of its ability to identify all bacteria in a urine sample. There are now several labs in the United States offering DNA UTI testing for international customers (testing technologies and costs vary between labs).
There is no consensus on the value of DNA-based molecular testing in diagnosing chronic UTIs. Some research experts are critical due to the current lack of understanding of the urinary microbiome and the inability to describe the microbes truly responsible for health and disease. In Australia, anecdotal reports so far highlight difficulties for people finding practitioners who understand the test results and have specialist knowledge in treating chronic UTI.
Although it is still early days, it is hoped that molecular testing will one day allow the identification of a personalised healthy urinary microbiome and inform future treatment options.
5 Diagnosing UTIs is ‘a dog’s breakfast,’ and that’s affecting women, The Current, CBC.CA, 3 April 2018, Radio www.cbc.ca/player/play/1201579075817. Accessed 15 September 2018.
6 Khasriya R, Khan S, Lunawat R, Bishara S, Bignal J, Malone-Lee M, et al. The Inadequacy of Urinary Dipstick and Microscopy as Surrogate Markers of Urinary Tract Infection in Urological Outpatients With Lower Urinary Tract Symptoms Without Acute Frequency and Dysuria. JUrol. 2010;183(5):1843-7. www.ncbi.nlm.nih.gov/pubmed/20303096
7 Kupelian AS, Horsley H, Khasriya R, Amussah RT, Badiani R, Courtney AM, et al. Discrediting microscopic pyuria and leucocyte esterase as diagnostic surrogates for infection in patients with lower urinary tract symptoms: results from a clinical and laboratory evaluation. BJU Int. 2013;112(2):231-8. doi: 10.1111/j.1464-410X.2012.11694.x. PubMed PMID: 23305196. www.ncbi.nlm.nih.gov/pubmed/23305196
8 Brubaker L, Wolfe AJ. The Female Urinary Microbiota/Microbiome: Clinical and Research Implications. Rambam Maimonides medical journal. 2017;8(2). Epub 2017/05/04. doi: 10.5041/rmmj.10292. PubMed PMID: 28467757; PubMed Central PMCID: PMCPMC5415361. www.ncbi.nlm.nih.gov/pubmed/28467757
9 Gill K, Kang R, Sathiananthamoorthy S, Khasriya R, Malone-Lee, J. A blinded observational cohort study of the microbiological ecology associated with pyuria and overactive bladder symptoms. Int Urogynecol J. 2018. Epub 2018/02/20. doi: 1007/s00192-018-3558-x. PubMed PMID: 29455238. www.ncbi.nlm.nih.gov/pubmed/29455238
10 Price, TK, Hilt EE, Dune TJ, Mueller ER, Wolfe AJ, Brubaker L., Urine trouble: should we think differently about UTI? International Urogynecology Journal doi.org/10.1007/s00192-017-3528-8, www.ncbi.nlm.nih.gov/pubmed/29279968
Compared with acute UTI, chronic UTI involves lower numbers of bacteria that invade the bladder lining and move in and out of a dormant (quiescent) state. These lower level bacterial loads will most likely fall well below the thresholds set for diagnosing acute UTI and are interpreted as ‘negative’11. Since chronic UTI is not a recognised condition, there has been no drive to introduce a second level test to diagnose UTIs that fall outside the existing diagnostic criteria (which were originally designed for diagnosing pyelonephritis).
11 Professor James Malone-Lee, Emeritus Professor of Nephrology, University College London, personal communication, 27 January 2018 www.chronicutiaustralia.com/chronic-uti/how-chronic-uti-forms/ Accessed 15 September 2018
In Professor Malone-Lee’s UK clinic, a chronic UTI diagnosis is based on a patient’s symptoms, history and signs of infection found by microscopy looking at an immediately fresh, unspun, unstained and undiluted urine sample. The microscopy is looking for evidence of white blood cells (pus cells fighting infection) and epithelial cells (shedding of the bladder lining as part of the natural immune response).
You can enquire about the clinic’s diagnostic and treatment protocol by contacting Professor Malone-Lee’s personal assistant, Martel Daley-Peart, E. firstname.lastname@example.org
You can also read-up on the LUTS treatment protocol in the following research papers, published 2018:
You can read a published opinion piece by Professor Malone-Lee published in the British Medical Journal in 2018:
This is absolutely true. Urine is not sterile12. This discovery is proving to be one of the biggest myth busters of the 21st century when it comes to bladder health and disease. As recently as 2012, scientists in the United States discovered a residential microbial community within the bladders of healthy women—dubbed the female urinary microbiota (FUM). Using DNA testing, researchers were able to identify over 400 different bacterial species living in both healthy women and women with lower urinary tract symptoms. Some of these species are thought to be beneficial and perform a protective role within the bladder.
This discovery is important because the traditional understanding of urinary infections, and the foundations UTI diagnostic testing was built on (in the 1950s), assumes healthy urine is sterile—and an isolated ‘known’ urinary pathogen (grown by culture) is responsible for infection. This is no longer the case. The discovery of the urinary microbiota is forcing scientists, microbiologists and clinicians to re-think everything previously accepted about bladder health and disease, including what causes UTIs and other urinary disorders—such as interstitial cystitis/painful bladder syndrome (IC/PBS), over active bladder syndrome (OAB) and urgency urinary incontinence (UUI)—and how these conditions are best diagnosed and treated.
12 Wolfe AJ, Toh E, Shibata N, et al. Evidence of uncultivated bacteria in the adult female bladder. J Clin Microbiol. 2012;50(4):1376-1383, jcm.asm.org/content/50/4/1376.full
Scientists have not yet reached a consensus as to why 25–35% of people with an acute UTI fail the standard antibiotic therapy prescribed13. However, researchers have shown that bacteria, such as E. coli, are able to communicate between themselves via a process known as ‘quorum sensing’. Such communication enables them to form biofilm-like intracellular bacterial communities early on during an acute infection, leaving behind a bacterial reservoir capable of seeding future acute attacks and/or ongoing lower urinary tract symptoms14.
13 Zalmanovici TA, Green H, Paul M, Yaphe J, Leibovici L. Antimicrobial agents for treating uncomplicated urinary tract infection in women. CochraneDatabaseSystRev.2010;(10):CD007182, cited in Malone-Lee J, Urinary infections are complex and hard to treat, BMJ 2017;359:j4784 www.bmj.com/content/359/bmj.j5766.full?ijkey=IiTCSBtWau0sm9j&keytype=ref
14 Opal SM, Communal Living by Bacteria and the Pathogenesis of Urinary Tract Infections. PLoS Med. 2007 Dec; 4(12): e349. Published online 2007 Dec 18; doi: 10.1371/journal. pmed.0040349 www.ncbi.nlm.nih.gov/pmc/articles/PMC2140084/
Presently, long-term, full-dose antibiotic therapy is the only readily effective treatment for people diagnosed with chronic UTI15. Researchers are desperately searching for fast, effective and safe alternatives to traditional antibiotics.
• Bacteriophage therapy (using viruses to attack pathogenic bacteria).
• Probiotics to return the urinary microbiota to a healthy state.
• Vaccination against select urinary pathogens.
• Super-strength mannosides to stop bacteria from becoming embedded in the bladder wall.
• New nanoparticle technology that administers the antibiotic directly into the bladder where it can reach uropathogens protected by biofilm and/or hiding inside the cells that line the bladder.
15 Swamy, S., Barcella, W., Iorio, M., Gill, K., Khasriya, R., Kupelian, A., ., Rohn, JL., Malone-Lee, J., Recalcitrant chronic bladder pain and recurrent cystitis but negative urinalysis: What should we do? International Urogynecology Journal, 29(7), 1035-1043; 2018; doi: 10.1007/s00192-018-3569-7 link.springer.com/article/10.1007/s00192-018-3569-7
Because chronic UTI is a poorly recognised condition that has no accurate diagnostic test, most people fail to achieve a proper diagnosis.
Commonly, people with chronic UTI are diagnosed with incurable ‘urinary syndromes’ like interstitial cystitis/painful bladder syndrome (IC/PBS), overactive bladder syndrome (OAB) or urinary urge incontinence (UUI). Diagnosis of a ‘urinary syndrome’ is usually made after seeking help from three to five different practitioners over a period of three to seven years16.
Chronic UTI is a debilitating condition. Many people with an untreated chronic UTI live with symptoms of distressing and incapacitating pain and constant urinary frequency and urgency—all of which significantly impact psychological and emotional health and wellbeing. If left untreated, chronic UTI ruins lives, relationships, self-confidence and the ability to work, be sexually intimate and manage families.
16 Interstitial Cystitis Fact Sheet, Women’s Health Queensland Wide, www.womhealth.org.au Accessed 27 February 2018
In Australia, there are currently no tests or treatment guidelines for chronic UTI. Not all doctors recognise chronic UTI as a disease or know how to treat it, so practitioners often vary in their approach.
However, there are Australians being treated for chronic UTI who have proactively researched the disease and partner with their doctor to treat their embedded infection using antimicrobials, traditional Chinese medicine or natural therapies.
How can you find out more?
You can talk to some of these people, and others who are researching and undergoing various therapies, in a number of online support/chat groups for chronic UTI. Please search on Facebook or contact us for a current list from the growing global network.
You can read more from others who have cured their chronic UTI using a variety of approaches on the Chronic UTI Australia blog. By subscribing to our blog, you will receive a free copy of our Understanding Chronic UTI booklet in PDF, plus a positive, real-life patient story will be delivered direct to your inbox each month. Click here to subscribe.
Unfortunately, we don’t have a list of Australian practitioners specialising in diagnosing and treating chronic UTI. However, there are a growing number of Australians being diagnosed and successfully treated for chronic UTI by either an international specialist or their own GP, urologist or treating microbiologist. You can read some of their stories on our blog.
There are Australians who have travelled to the UK for a diagnosis and treatment plan. Once back in Australia, these patients continue to work with their local doctor, while also being supported throughout by UK UTI specialist, Professor James Malone-Lee. Please use the contact details below if you wish to make a face-to-face appointment at the London clinic.
Professor Malone-Lee also welcomes direct contact by international doctors enquiring about the treatment protocol used at the London clinic, and who are looking to diagnose and treat their own patients with suspected chronic UTI.
Professor James Malone-Lee (private clinic)
10 Harley Street, London
(Martel Daley-Peart, Personal Assistant)
T. 0011 +44 07 568 403 211
Dr Ased Ali (Yorkshire Urology private clinic)
Methley Land, Leeds LS269HG
T. 0011 +44 01977 664 230
If you need a little more help getting started on your journey, please connect with us by email, Facebook or Twitter.